Scientists believe antihistamines may help cure protracted COVID: treatment discovered by accident

Scientists believe antihistamines may help cure protracted COVID: treatment discovered by accident

Antihistamines could provide relief to millions of people suffering from the painful and debilitating symptoms of long-term COVID, which can be so severe as to affect daily life.

The impact of COVID-19 on people can range from mild symptoms to weeks of illness, but various ailments, including confusion, joint pain and fatigue, can last for months after initial infection – collectively known as protracted COVID.

The realization that antihistamines could provide some relief came by chance after two otherwise healthy, active middle-aged women with long-term COVID found the pills helped.

Both women, who have not been identified, were taking over-the-counter antihistamines to treat other conditions.

Two long-term COVID patients in California, one of whom was a healthcare worker, had almost complete relief of their symptoms by taking daily antihistamines.

Two long-term COVID patients in California, one of whom was a healthcare worker, had almost complete relief of their symptoms by taking daily antihistamines.

The first woman, a healthcare worker in her 40s, induced a dairy allergy by eating cheese, and the second woman ran out of her usual allergy medication and felt better cognitive function and much less fatigue the next morning.

In the first case, a woman with long-term COVID-19 was unable to exercise and suffered from chest pains, headaches, rashes and bruising, while in the second she had to deal with joint and abdominal pain, as well as rashes and lesions. known as “COVID fingers”. She is believed to have been one of the first people in the United States to contract COVID.

In the first case, after she accidentally ate some cheese about six months after prolonged COVID, she took a 50mg tablet of the antihistamine diphenhydramine and suddenly noticed that her fatigue had virtually disappeared.

The woman has not taken other antihistamines within 72 hours; when her symptoms reappeared, she took the medicine and felt better again.

Her doctor then prescribed a daily dose of antihistamines, which significantly reduced her long-term symptoms of COVID-19. She eventually reported that she had regained 90 percent of her daily functions prior to COVID-19. Nine months later, she is said to still be doing well.

The evidence is anecdotal, but similar positive results with antihistamines have been found in earlier studies.

The evidence is anecdotal, but similar positive results with antihistamines have been found in earlier studies.

In the second case, the woman was taking a different over-the-counter antihistamine instead of what she had been taking for years to treat seasonal allergies.

She noticed that her long-term COVID-19 fatigue and general cognition improved. She also continued to take it daily along with other allergy medications.

The second woman also found that she significantly reduced her additional long-term symptoms of COVID-19, restoring 95 percent of her overall functioning before contracting the disease.

Both cases were studied by nurse scientists at the University of California, Irvine, the results of which were published in the Journal for Nurse Practitioners.

“Patients tell us that what they want more than anything is that they can work and do the most basic things they are used to before they get sick with long-term COVID. They are desperately looking for something to help them get back on their feet,” report author Melissa Pinto, assistant professor of nursing at the University of California, Irvine, told UCI News.

“Patients tell us that what they want more than anything is that they can work and do the most basic things they are used to before they get sick with long-term COVID.  They are desperately looking for something to help them get back on their feet,” said report author Melissa Pinto.  approximately 54 million people around the world who are in distress for months or even years.”

“Patients tell us that what they want more than anything is that they can work and do the most basic things they are used to before they get sick with long-term COVID. They are desperately looking for something to help them get back on their feet,” said report author Melissa Pinto. approximately 54 million people around the world who are in distress for months or even years.”

“Currently there is no cure for [for long COVID], only treatment of symptoms. A number of options are being tested, one of which is antihistamines. The possibility that a readily available over-the-counter drug can relieve some of the symptoms should give hope to the estimated 54 million people around the world who are in distress for months or even years.”

If true, this would be consistent with what was found in earlier studies, including those documented in the Journal of Investigative Medicine and Pulmonary Pharmacology & Therapeutics, which also showed similar benefits to using antihistamines to treat long-term COVID.

“Most patients tell us that doctors didn’t recommend anything that would help. If patients want to try over-the-counter antihistamines, I encourage them to do so under medical supervision. And since providers may not be aware of new potential treatments, I would encourage patients to be proactive in their care and consider doing research and case reports like ours to appointments with providers so they can help create a regimen that will work. ‘, Pinto said.

“The next steps in this antihistamine treatment trial are to conduct large-scale trials to evaluate efficacy and develop dosing regimens for clinical practice guidelines.”

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